Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish

Nrf2 plays critical roles in animals’ defense against electrophiles and oxidative stress by orchestrating the induction of cytoprotective genes. We previously isolated the zebrafish mutant it768, which displays up-regulated expression of Nrf2 target genes in an uninduced state. In this paper, we det...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Mukaigasa, Katsuki, Tsujita, Tadayuki, Nguyen, Vu Thanh, Li, Li, Yagi, Hirokazu, Fuse, Yuji, Nakajima-Takagi, Yaeko, Kato, Koichi, Yamamoto, Masayuki, Kobayashi, Makoto
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856520/
https://ncbi.nlm.nih.gov/pubmed/29472449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714056115
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