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Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum

Nrf1 (nuclear factor-erythroid 2 p45 subunit-related factor 1) and Nrf2 regulate ARE (antioxidant response element)-driven genes. At its N-terminal end, Nrf1 contains 155 additional amino acids that are absent from Nrf2. This 155-amino-acid polypeptide includes the N-terminal domain (NTD, amino acid...

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Sonraí Bibleagrafaíochta
Main Authors: Zhang, Yiguo, Crouch, Dorothy H., Yamamoto, Masayuki, Hayes, John D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Portland Press Ltd. 2006
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615900/
https://ncbi.nlm.nih.gov/pubmed/16872277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060725
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