Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish

Nrf2 plays critical roles in animals’ defense against electrophiles and oxidative stress by orchestrating the induction of cytoprotective genes. We previously isolated the zebrafish mutant it768, which displays up-regulated expression of Nrf2 target genes in an uninduced state. In this paper, we det...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Mukaigasa, Katsuki, Tsujita, Tadayuki, Nguyen, Vu Thanh, Li, Li, Yagi, Hirokazu, Fuse, Yuji, Nakajima-Takagi, Yaeko, Kato, Koichi, Yamamoto, Masayuki, Kobayashi, Makoto
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856520/
https://ncbi.nlm.nih.gov/pubmed/29472449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1714056115
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