Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

Excessive nitric oxide (NO) production in cytokine-activated β cells has been implicated in β cell disruption in type 1 diabetes. β cells are very vulnerable to NO-induced apoptosis. However, the mechanism underlying this phenomenon is unclear. Low concentrations of NO that lead to apoptosis apparen...

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Detalhes bibliográficos
Main Authors: Oyadomari, Seiichi, Takeda, Kiyoshi, Takiguchi, Masaki, Gotoh, Tomomi, Matsumoto, Makoto, Wada, Ikuo, Akira, Shizuo, Araki, Eiichi, Mori, Masataka
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC58562/
https://ncbi.nlm.nih.gov/pubmed/11526215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191207498
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