Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy

BACKGROUND: Tauopathies comprise a family of neurodegenerative disorders including Alzheimer’s disease for which there is an urgent and unmet need for disease-modifying treatments. Tauopathies are characterized by pathological tau hyperphosphorylation, which has been shown to correlate tightly with...

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Bibliografski detalji
Izdano u:Transl Neurodegener
Glavni autori: Alavi Naini, Seyedeh Maryam, Yanicostas, Constantin, Hassan-Abdi, Rahma, Blondeel, Sébastien, Bennis, Mohamed, Weiss, Ryan J., Tor, Yitzhak, Esko, Jeffrey D., Soussi-Yanicostas, Nadia
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Short Report
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855975/
https://ncbi.nlm.nih.gov/pubmed/29568517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-018-0111-2
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