Benzothiophenone Derivatives Targeting Mutant Forms of Estrogen Receptor-α in Hormone-Resistant Breast Cancers

Estrogen receptor-α positive (ERα(+)) breast cancers represent 75% of all invasive breast cancer cases, while de novo or acquired resistance to ER-directed therapy is also on the rise. Numerous factors contribute to this phenomenon including the recently-reported ESR1 gene mutations such as Y537S, w...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Singh, Kriti, Munuganti, Ravi S. N., Lallous, Nada, Dalal, Kush, Yoon, Ji Soo, Sharma, Aishwariya, Yamazaki, Takeshi, Cherkasov, Artem, Rennie, Paul S.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855801/
https://ncbi.nlm.nih.gov/pubmed/29462880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19020579
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