Enzalutamide-induced “BRCAness” and PARP inhibition is a synthetic lethal therapy for castration-resistant prostate cancer

Cancers with dysfunctional mutations in BRCA1 or BRCA2, most commonly associated with some breast cancers, are deficient in the DNA damage repair pathway called homologous recombination (HR), which makes them exquisitely vulnerable to poly(ADP-ribose) polymerase (PARP) inhibitors, such as olaparib....

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Udgivet i:Sci Signal
Main Authors: Li, Likun, Karanika, Styliani, Yang, Guang, Wang, Jiangxiang, Park, Sanghee, Broom, Bradley, Manyam, Ganiraju C., Wu, Wenhui, Luo, Yong, Basourakos, Spyridon, Song, Jian H., Gallick, Gary E., Karantanos, Theodoros, Korentzelos, Dimitrios, Azad, Abul Kalam, Kim, Jeri, Corn, Paul G., Aparicio, Ana M., Logothesis, Christopher J., Troncoso, Particia, Timothy, Heffernan, Toniatti, Carlo, Lee, Hyun-Sung, Lee, Ju-Seog, Zuo, Xuemei, Chang, Wenjun, Yin, Jianhua, Thompson, Timothy C.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5855082/
https://ncbi.nlm.nih.gov/pubmed/28536297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aam7479
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