Targeting DNA damage response in prostate cancer through inhibition of androgen receptor/CDC6-ATR-Chk1 signaling: Combined AR/CDC6 and Chk1/2 inhibition for PCa

Cell division cycle 6 (CDC6), an androgen receptor (AR) target gene, is implicated in regulating DNA replication and checkpoint mechanisms. CDC6 is increased during prostate cancer (PCa) progression and positively correlates with AR in PCa tissues. AR or CDC6 knockdown together with AZD7762, a Chk1/...

Szczegółowa specyfikacja

Zapisane w:
Opis bibliograficzny
Wydane w:Cell Rep
Główni autorzy: Karanika, Styliani, Karantanos, Theodoros, Li, Likun, Wang, Jianxiang, Park, Sanghee, Yang, Guang, Zuo, Xuemei, Song, Jian H., Maity, Sankar N., Manyam, Ganiraju C., Broom, Bradley, Aparicio, Ana M., Gallick, Gary, Troncoso, Patricia, Corn, Paul G., Navone, Nora, Zhang, Wei, Li, Shuhua, Thompson., Timothy C.
Format: Artigo
Język:Inglês
Wydane: 2017
Hasła przedmiotowe:
Article
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349188/
https://ncbi.nlm.nih.gov/pubmed/28228262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.01.072
Etykiety: Dodaj etykietę
Nie ma etykietki, Dołącz pierwszą etykiete!

Podobne zapisy