Lipid peroxidation regulates podocyte migration and cytoskeletal structure through redox sensitive RhoA signaling

Early podocyte loss is characteristic of chronic kidney diseases (CKD) in obesity and diabetes. Since treatments for hyperglycemia and hypertension do not prevent podocyte loss, there must be additional factors causing podocyte depletion. The role of oxidative stress has been implicated in CKD but i...

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Gepubliceerd in:Redox Biol
Hoofdauteurs: Kruger, Claudia, Burke, Susan J., Collier, J. Jason, Nguyen, Trang-Tiffany, Salbaum, J. Michael, Stadler, Krisztian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2018
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854917/
https://ncbi.nlm.nih.gov/pubmed/29547847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.02.024
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