Amelioration of Crescentic Glomerulonephritis by RhoA Kinase Inhibitor, Fasudil, through Podocyte Protection and Prevention of Leukocyte Migration

The small GTPase RhoA is activated by the angiotensin II (AngII) type 1 receptor (AT1R), which is part of the local renin-angiotensin system that is involved in podocyte injury preceding glomerular crescent formation. We demonstrated previously that inhibition of AT1R protects against crescentic glo...

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Detalhes bibliográficos
Main Authors: Hidaka, Teruo, Suzuki, Yusuke, Yamashita, Michifumi, Shibata, Terumi, Tanaka, Yuichi, Horikoshi, Satoshi, Tomino, Yasuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258248/
https://ncbi.nlm.nih.gov/pubmed/18245810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070196
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