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VTA mTOR Signaling Regulates Dopamine Dynamics, Cocaine-Induced Synaptic Alterations, and Reward

Mechanistic target of rapamycin (mTOR) regulates long-term synaptic plasticity, learning, and memory by controlling dendritic protein synthesis. The mTOR inhibitor rapamycin has been shown to attenuate the behavioral effects of drugs of abuse, including cocaine. Using viral vectors to selectively de...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Liu, Xiaojie, Li, Yan, Yu, Laikang, Vickstrom, Casey R, Liu, Qing-song
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854804/
https://ncbi.nlm.nih.gov/pubmed/29039413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2017.247
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