Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death

BMP signaling plays a critical role in craniofacial development. Augmentation of BMPR1A signaling through neural crest-specific expression of constitutively active Bmpr1a (caBmpr1a) results in craniofacial deformities in mice. To investigate whether deletion of Tak1 may rescue the craniofacial defor...

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Detalhes bibliográficos
Publicado no:Genesis
Main Authors: Liu, Xia, Hayano, Satoru, Pan, Haichun, Inagaki, Maiko, Ninomiya-Tsuji, Jun, Sun, Hongchen, Mishina, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854540/
https://ncbi.nlm.nih.gov/pubmed/29411501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvg.23093
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