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Flow cytometric method for scoring rat liver micronuclei with simultaneous assessments of hepatocyte proliferation

The current report describes a newly devised method for automatically scoring the incidence of rat hepatocyte micronuclei (MNHEP) via flow cytometry, with concurrent assessments of hepatocyte proliferation—frequency of Ki-67-positive nuclei, and the proportion of polyploid nuclei. Proof-of-concept d...

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Detalhes bibliográficos
Publicado no:Environ Mol Mutagen
Main Authors: Avlasevich, Svetlana L., Khanal, Sumee, Singh, Priyanka, Torous, Dorothea K., Bemis, Jeffrey C., Dertinger, Stephen D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854533/
https://ncbi.nlm.nih.gov/pubmed/29356121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22168
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