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Hereditary cancer genes are highly susceptible to splicing mutations
Substitutions that disrupt pre-mRNA splicing are a common cause of genetic disease. On average, 13.4% of all hereditary disease alleles are classified as splicing mutations mapping to the canonical 5′ and 3′ splice sites. However, splicing mutations present in exons and deeper intronic positions are...
Tallennettuna:
| Julkaisussa: | PLoS Genet |
|---|---|
| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Public Library of Science
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5854443/ https://ncbi.nlm.nih.gov/pubmed/29505604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007231 |
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