Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor

EGFR-based targeted therapies have shown limited success in smokers. Identification of alternate signaling mechanism(s) leading to TKI resistance in smokers is critically important. We observed increased resistance to erlotinib in H358 NSCLC (non-small cell lung carcinoma) cells chronically exposed...

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Опубликовано в: :Oncoscience
Главные авторы: Solanki, Hitendra S., Raja, Remya, Zhavoronkov, Alex, Ozerov, Ivan V., Artemov, Artem V., Advani, Jayshree, Radhakrishnan, Aneesha, Babu, Niraj, Puttamallesh, Vinuth N., Syed, Nazia, Nanjappa, Vishalakshi, Subbannayya, Tejaswini, Sahasrabuddhe, Nandini A., Patil, Arun H., Prasad, T.S. Keshava, Gaykalova, Daria, Chang, Xiaofei, Sathyendran, Rachana, Mathur, Premendu Prakash, Rangarajan, Annapoorni, Sidransky, David, Pandey, Akhilesh, Izumchenko, Evgeny, Gowda, Harsha, Chatterjee, Aditi
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2018
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Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854290/
https://ncbi.nlm.nih.gov/pubmed/29556515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncoscience.395
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