Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor

EGFR-based targeted therapies have shown limited success in smokers. Identification of alternate signaling mechanism(s) leading to TKI resistance in smokers is critically important. We observed increased resistance to erlotinib in H358 NSCLC (non-small cell lung carcinoma) cells chronically exposed...

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Bibliographic Details
Published in:Oncoscience
Main Authors: Solanki, Hitendra S., Raja, Remya, Zhavoronkov, Alex, Ozerov, Ivan V., Artemov, Artem V., Advani, Jayshree, Radhakrishnan, Aneesha, Babu, Niraj, Puttamallesh, Vinuth N., Syed, Nazia, Nanjappa, Vishalakshi, Subbannayya, Tejaswini, Sahasrabuddhe, Nandini A., Patil, Arun H., Prasad, T.S. Keshava, Gaykalova, Daria, Chang, Xiaofei, Sathyendran, Rachana, Mathur, Premendu Prakash, Rangarajan, Annapoorni, Sidransky, David, Pandey, Akhilesh, Izumchenko, Evgeny, Gowda, Harsha, Chatterjee, Aditi
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854290/
https://ncbi.nlm.nih.gov/pubmed/29556515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncoscience.395
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