Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor

EGFR-based targeted therapies have shown limited success in smokers. Identification of alternate signaling mechanism(s) leading to TKI resistance in smokers is critically important. We observed increased resistance to erlotinib in H358 NSCLC (non-small cell lung carcinoma) cells chronically exposed...

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Detalhes bibliográficos
Publicado no:Oncoscience
Main Authors: Solanki, Hitendra S., Raja, Remya, Zhavoronkov, Alex, Ozerov, Ivan V., Artemov, Artem V., Advani, Jayshree, Radhakrishnan, Aneesha, Babu, Niraj, Puttamallesh, Vinuth N., Syed, Nazia, Nanjappa, Vishalakshi, Subbannayya, Tejaswini, Sahasrabuddhe, Nandini A., Patil, Arun H., Prasad, T.S. Keshava, Gaykalova, Daria, Chang, Xiaofei, Sathyendran, Rachana, Mathur, Premendu Prakash, Rangarajan, Annapoorni, Sidransky, David, Pandey, Akhilesh, Izumchenko, Evgeny, Gowda, Harsha, Chatterjee, Aditi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854290/
https://ncbi.nlm.nih.gov/pubmed/29556515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncoscience.395
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