Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues

Failure of neural tube closure leads to neural tube defects (NTDs), common congenital abnormalities in humans. Among the genes whose loss of function causes NTDs in mice, Grainyhead-like3 (Grhl3) is essential for spinal neural tube closure, with null mutants exhibiting fully penetrant spina bifida....

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Publicat a:Dev Biol
Autors principals: De Castro, Sandra C.P., Hirst, Caroline S., Savery, Dawn, Rolo, Ana, Lickert, Heiko, Andersen, Bogi, Copp, Andrew J., Greene, Nicholas D.E.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854268/
https://ncbi.nlm.nih.gov/pubmed/29397878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2018.01.016
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