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Physiological functions of programmed DNA breaks in signal-induced transcription

The idea that signal-dependent transcription might involve the generation of transient DNA nicks or even breaks in the regulatory regions of genes, accompanied by activation of DNA damage repair pathways, would seem to be counterintuitive, as DNA damage is usually considered harmful to cellular inte...

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Bibliografske podrobnosti
izdano v:Nat Rev Mol Cell Biol
Main Authors: Puc, Janusz, Aggarwal, Aneel K., Rosenfeld, Michael G.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854152/
https://ncbi.nlm.nih.gov/pubmed/28537575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm.2017.43
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