Transcriptional elongation requires DNA break-induced signalling

We have previously shown that RNA polymerase II (Pol II) pause release and transcriptional elongation involve phosphorylation of the factor TRIM28 by the DNA damage response (DDR) kinases ATM and DNA-PK. Here we report a significant role for DNA breaks and DDR signalling in the mechanisms of transcr...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Bunch, Heeyoun, Lawney, Brian P., Lin, Yu-Fen, Asaithamby, Aroumougame, Murshid, Ayesha, Wang, Yaoyu E., Chen, Benjamin P. C., Calderwood, Stuart K.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703865/
https://ncbi.nlm.nih.gov/pubmed/26671524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10191
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