Transcriptional elongation requires DNA break-induced signalling

We have previously shown that RNA polymerase II (Pol II) pause release and transcriptional elongation involve phosphorylation of the factor TRIM28 by the DNA damage response (DDR) kinases ATM and DNA-PK. Here we report a significant role for DNA breaks and DDR signalling in the mechanisms of transcr...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Bunch, Heeyoun, Lawney, Brian P., Lin, Yu-Fen, Asaithamby, Aroumougame, Murshid, Ayesha, Wang, Yaoyu E., Chen, Benjamin P. C., Calderwood, Stuart K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703865/
https://ncbi.nlm.nih.gov/pubmed/26671524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10191
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