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Innate Immune Response and Outcome of Clostridium difficile Infection Are Dependent on Fecal Bacterial Composition in the Aged Host

BACKGROUND: Clostridium difficile infection (CDI) is a serious threat for an aging population. Using an aged mouse model, we evaluated the effect of age and the roles of innate immunity and intestinal microbiota. METHODS: Aged (18 months) and young (8 weeks) mice were infected with C difficile, and...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Infect Dis
Main Authors: Shin, Jae Hyun, Gao, Yingnan, Moore, John H, Bolick, David T, Kolling, Glynis L, Wu, Martin, Warren, Cirle A
פורמט: Artigo
שפה:Inglês
יצא לאור: Oxford University Press 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853981/
https://ncbi.nlm.nih.gov/pubmed/28968660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix414
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