Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver

Both Ebola virus (EBOV) and Reston virus (RESTV) cause disease in nonhuman primates, yet only EBOV causes disease in humans. To investigate differences in viral pathogenicity, humanized mice (hu-NSG-SGM3) were inoculated with EBOV or RESTV. Consistent with differences in disease in human infection,...

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Veröffentlicht in:J Infect Dis
Hauptverfasser: Spengler, Jessica R, Saturday, Greg, Lavender, Kerry J, Martellaro, Cynthia, Keck, James G, Nichol, Stuart T, Spiropoulou, Christina F, Feldmann, Heinz, Prescott, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Major Articles and Brief Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853858/
https://ncbi.nlm.nih.gov/pubmed/29087482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix562
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