Ebola Virus Replication and Disease Without Immunopathology in Mice Expressing Transgenes to Support Human Myeloid and Lymphoid Cell Engraftment

The study of Ebola virus (EBOV) pathogenesis in vivo has been limited to nonhuman primate models or use of an adapted virus to cause disease in rodent models. Herein we describe wild-type EBOV (Makona variant) infection of mice engrafted with human hematopoietic CD34(+) stem cells (Hu-NSG™-SGM3 mice...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Spengler, Jessica R., Lavender, Kerry J., Martellaro, Cynthia, Carmody, Aaron, Kurth, Andreas, Keck, James G., Saturday, Greg, Scott, Dana P., Nichol, Stuart T., Hasenkrug, Kim J., Spiropoulou, Christina F., Feldmann, Heinz, Prescott, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Ebola Outbreak in West Africa
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050473/
https://ncbi.nlm.nih.gov/pubmed/27601621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiw248
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