Intramuscular Adeno-Associated Virus–Mediated Expression of Monoclonal Antibodies Provides 100% Protection Against Ebola Virus Infection in Mice

The 2013–2016 West Africa outbreak demonstrated the epidemic potential of Ebola virus and highlighted the need for counter strategies. Monoclonal antibody (mAb)–based therapies hold promise as treatment options for Ebola virus infections. However, production of clinical-grade mAbs is labor intensive...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: van Lieshout, Laura P, Soule, Geoff, Sorensen, Debra, Frost, Kathy L, He, Shihua, Tierney, Kevin, Safronetz, David, Booth, Stephanie A, Kobinger, Gary P, Qiu, Xiangguo, Wootton, Sarah K
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5853240/
https://ncbi.nlm.nih.gov/pubmed/29365142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jix644
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