Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

The human genome is generally organized into stable chromosomes, and only tumor cells are known to accumulate kilobase (kb)-sized extrachromosomal circular DNA elements (eccDNAs). However, it must be expected that kb eccDNAs exist in normal cells as a result of mutations. Here, we purify and sequenc...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Møller, Henrik Devitt, Mohiyuddin, Marghoob, Prada-Luengo, Iñigo, Sailani, M. Reza, Halling, Jens Frey, Plomgaard, Peter, Maretty, Lasse, Hansen, Anders Johannes, Snyder, Michael P., Pilegaard, Henriette, Lam, Hugo Y. K., Regenberg, Birgitte
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852086/
https://ncbi.nlm.nih.gov/pubmed/29540679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03369-8
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