Compression force sensing regulates integrin α(IIb)β(3) adhesive function on diabetic platelets

Diabetes is associated with an exaggerated platelet thrombotic response at sites of vascular injury. Biomechanical forces regulate platelet activation, although the impact of diabetes on this process remains ill-defined. Using a biomembrane force probe (BFP), we demonstrate that compressive force ac...

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Publicado no:Nat Commun
Main Authors: Ju, Lining, McFadyen, James D., Al-Daher, Saheb, Alwis, Imala, Chen, Yunfeng, Tønnesen, Lotte L., Maiocchi, Sophie, Coulter, Brianna, Calkin, Anna C., Felner, Eric I., Cohen, Neale, Yuan, Yuping, Schoenwaelder, Simone M., Cooper, Mark E., Zhu, Cheng, Jackson, Shaun P.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852038/
https://ncbi.nlm.nih.gov/pubmed/29540687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03430-6
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