Compression force sensing regulates integrin α(IIb)β(3) adhesive function on diabetic platelets

Diabetes is associated with an exaggerated platelet thrombotic response at sites of vascular injury. Biomechanical forces regulate platelet activation, although the impact of diabetes on this process remains ill-defined. Using a biomembrane force probe (BFP), we demonstrate that compressive force ac...

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Argitaratua izan da:Nat Commun
Egile Nagusiak: Ju, Lining, McFadyen, James D., Al-Daher, Saheb, Alwis, Imala, Chen, Yunfeng, Tønnesen, Lotte L., Maiocchi, Sophie, Coulter, Brianna, Calkin, Anna C., Felner, Eric I., Cohen, Neale, Yuan, Yuping, Schoenwaelder, Simone M., Cooper, Mark E., Zhu, Cheng, Jackson, Shaun P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5852038/
https://ncbi.nlm.nih.gov/pubmed/29540687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03430-6
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