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A small group of sulfated benzofurans induces steady-state submaximal inhibition of thrombin
Despite the development of promising direct oral anticoagulants, which are all orthosteric inhibitors, a sizable number of patients suffer from bleeding complications. We have hypothesized that allosterism based on the heparin-binding exosites presents a major opportunity to induce sub-maximal inhib...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5851871/ https://ncbi.nlm.nih.gov/pubmed/29459207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.01.069 |
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