A Chemical-Genetic Approach Reveals the Distinct Roles of GSK3α and GSK3β in Regulating Embryonic Stem Cell Fate

Glycogen synthase kinase 3 (GSK3) plays a central role in diverse cellular processes. GSK3 has two mammalian isozymes, GSK3α and GSK3β, whose functions remain ill-defined because of a lack of inhibitors that can distinguish between the two highly homologous isozymes. Here, we show that GSK3α and GSK...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Dev Cell
Prif Awduron: Chen, Xi, Wang, Ruizhe, Liu, Xu, Wu, Yongming, Zhou, Tao, Yang, Yujia, Perez, Andrew, Chen, Ying-Chu, Hu, Liang, Chadarevian, Jean Paul, Assadieskandar, Amir, Zhang, Chao, Ying, Qi-Long
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851779/
https://ncbi.nlm.nih.gov/pubmed/29207259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.11.007
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg