A Chemical-Genetic Approach Reveals the Distinct Roles of GSK3α and GSK3β in Regulating Embryonic Stem Cell Fate

Glycogen synthase kinase 3 (GSK3) plays a central role in diverse cellular processes. GSK3 has two mammalian isozymes, GSK3α and GSK3β, whose functions remain ill-defined because of a lack of inhibitors that can distinguish between the two highly homologous isozymes. Here, we show that GSK3α and GSK...

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Veröffentlicht in:Dev Cell
Hauptverfasser: Chen, Xi, Wang, Ruizhe, Liu, Xu, Wu, Yongming, Zhou, Tao, Yang, Yujia, Perez, Andrew, Chen, Ying-Chu, Hu, Liang, Chadarevian, Jean Paul, Assadieskandar, Amir, Zhang, Chao, Ying, Qi-Long
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851779/
https://ncbi.nlm.nih.gov/pubmed/29207259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.11.007
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