Biomolecular study of human thymidylate synthase conformer-selective inhibitors: New chemotherapeutic approach

Thymidylate synthase (TS) is a well-validated target for the therapy of adult cancers. Propane-1,3-diphosphonic acid (PDPA) has significant inhibitory properties against human thymidylate synthase (hTS) relative to mouse TS which is not predicted to adopt an inactive conformer. The current research...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: El-Mesallamy, Hala O., El Magdoub, Hekmat M., Chapman, James M., Hamdy, Nadia M., Schaalan, Mona F., Hammad, Lamiaa N., Berger, Sondra H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851609/
https://ncbi.nlm.nih.gov/pubmed/29538414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193810
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