Plumbagin induces RPE cell cycle arrest and apoptosis via p38 MARK and PI3K/AKT/mTOR signaling pathways in PVR

BACKGROUND: This study aimed to explore the effects of plumbagin (PLB) on ARPE-19 cells and underlying mechanism. METHODS: Cultured ARPE-19 cells were treated with various concentrations (0, 5, 15, and 25 μM) of PLB for 24 h or with 15 μM PLB for 12, 24 and 48 h. Then cell viability was evaluated by...

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Detalhes bibliográficos
Publicado no:BMC Complement Altern Med
Main Authors: Chen, Haiting, Wang, Huifang, An, Jianbin, Shang, Qingli, Ma, Jingxue
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851073/
https://ncbi.nlm.nih.gov/pubmed/29534723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12906-018-2155-3
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