Infiltrating T cells increase IDO1 expression in glioblastoma and contribute to decreased patient survival

PURPOSE: Indoleamine 2,3 dioxygenase 1 (IDO1) mediates potent immunosuppression in multiple preclinical models of cancer. However, the basis for elevated IDO1 expression in human cancer, including the most common primary malignant brain tumor in adults, glioblastoma (GBM), is poorly understood. The...

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Bibliografiske detaljer
Udgivet i:Clin Cancer Res
Main Authors: Zhai, Lijie, Ladomersky, Erik, Lauing, Kristen, Wu, Meijing, Genet, Matthew, Gritsina, Galina, Győrffy, Balázs, Brastianos, Priscilla K., Binder, David C., Sosman, Jeffrey A., Giles, Francis J., James, Charles D., Horbinski, Craig, Stupp, Roger, Wainwright, Derek A.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850948/
https://ncbi.nlm.nih.gov/pubmed/28751450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0120
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