Non-tumor cell IDO1 predominantly contributes to enzyme activity and response to CTLA-4/PD-L1 inhibition in mouse glioblastoma

Glioblastoma (GBM) is the most common malignant brain tumor in adults with a median survival of 14.6 months. A contributing factor to GBM aggressiveness is the intratumoral expression of the potently immunosuppresive enzyme, indoleamine 2,3 dioxygenase 1 (IDO1). The enzymatic activity of IDO1 is ass...

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Udgivet i:Brain Behav Immun
Main Authors: Zhai, Lijie, Ladomersky, Erik, Dostal, Carlos R., Lauing, Kristen, Swoap, Kathleen, Billingham, Leah K., Gritsina, Galina, Wu, Meijing, McCusker, Robert H., Binder, David C., Wainwright, Derek A.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514839/
https://ncbi.nlm.nih.gov/pubmed/28179106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2017.01.022
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