Regulation of CNKSR2 protein stability by the HECT E3 ubiquitin ligase Smurf2, and its role in breast cancer progression

BACKGROUND: Smurf2 E3 ubiquitin ligase physically associates with and regulate the stability of distinct cellular protein substrates. The multi-functional scaffold protein Connector enhancer of kinase suppressor of ras 2 (CNKSR2) plays a key role in regulating cell proliferation, and differentiation...

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Publicat a:BMC Cancer
Autors principals: David, Diana, Surendran, Arun, Thulaseedharan, Jissa V., Nair, Asha S.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850909/
https://ncbi.nlm.nih.gov/pubmed/29534682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4188-x
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