Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings

BACKGROUND: Intoxication by nerve agents could be prevented by using small acetylcholinesterase inhibitors (eg, pyridostigmine) for potentially exposed personnel. However, the serious side effects of currently used drugs led to research of novel potent molecules for prophylaxis of organophosphorus i...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Kuca, Kamil, Karasova, Jana Zdarova, Soukup, Ondrej, Kassa, Jiri, Novotna, Eva, Sepsova, Vendula, Horova, Anna, Pejchal, Jaroslav, Hrabinova, Martina, Vodakova, Eva, Jun, Daniel, Nepovimova, Eugenie, Valis, Martin, Musilek, Kamil
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849933/
https://ncbi.nlm.nih.gov/pubmed/29563775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S133038
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