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Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones

Clinical failure of novel drugs is often related to their rapid metabolism and excretion. This highlights the importance of elucidation of their pharmacokinetic profile already at the preclinical stage of drug development. Triapine, the most prominent representative of α-N-heterocyclic thiosemicarba...

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Dades bibliogràfiques
Publicat a:Anal Bioanal Chem
Autors principals: Pelivan, Karla, Frensemeier, Lisa M., Karst, Uwe, Koellensperger, Gunda, Heffeter, Petra, Keppler, Bernhard K., Kowol, Christian R.
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5849672/
https://ncbi.nlm.nih.gov/pubmed/29476231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-018-0889-x
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