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Optical control of GPR40 signalling in pancreatic β-cells
Fatty acids activate GPR40 and K(+) channels to modulate β-cell function. Herein, we describe the design and synthesis of FAAzo-10, a light-controllable GPR40 agonist based on Gw-9508. FAAzo-10 is a potent GPR40 agonist in the trans-configuration and can be inactivated on isomerization to cis with U...
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| Publicat a: | Chem Sci |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Royal Society of Chemistry
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5848828/ https://ncbi.nlm.nih.gov/pubmed/29568424 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc01475a |
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