A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma

Pre-mRNA splicing can contribute to the switch of cell identity that occurs in carcinogenesis. Here, we analyze a large collection of RNA-seq data sets and report that splicing changes in hepatocyte-specific enzymes, such as AFMID and KHK, are associated with HCC patients’ survival and relapse. The...

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Publicat a:Genome Res
Autors principals: Lin, Kuan-Ting, Ma, Wai Kit, Scharner, Juergen, Liu, Yun-Ru, Krainer, Adrian R.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5848607/
https://ncbi.nlm.nih.gov/pubmed/29449409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.227181.117
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