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Premutilin synthase: Ring rearrangement by a class II diterpene cyclase
Biosynthesis of the complex diterpenoid antibiotic pleuromutilin relies on a bifunctional (di)terpene synthase and here site-directed mutagenesis was used to knock-out either of the two active sites. This enabled characterization of the novel ring contracted intermediate produced by the initiating c...
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| Gepubliceerd in: | Org Lett |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5848098/ https://ncbi.nlm.nih.gov/pubmed/29388775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b00121 |
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