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Premutilin synthase: Ring rearrangement by a class II diterpene cyclase

Biosynthesis of the complex diterpenoid antibiotic pleuromutilin relies on a bifunctional (di)terpene synthase and here site-directed mutagenesis was used to knock-out either of the two active sites. This enabled characterization of the novel ring contracted intermediate produced by the initiating c...

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Bibliografische gegevens
Gepubliceerd in:Org Lett
Hoofdauteurs: Xu, Meimei, Jia, Meirong, Hong, Young J., Yin, Xihou, Tantillo, Dean J., Proteau, Philip J., Peters, Reuben J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5848098/
https://ncbi.nlm.nih.gov/pubmed/29388775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b00121
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