STATINS ACCELERATE DISEASE PROGRESSION AND SHORTEN SURVIVAL IN SOD1(G93A) MICE

INTRODUCTION: HMG-CoA reductase inhibitors (statins) and H63D HFE polymorphism may modify amyotrophic lateral sclerosis (ALS). We hypothesized that statins worsen phenotype in ALS mice, dependent on HFE genotype. METHODS: Mice harboring SOD1(G93A) heterozygous for H67D Hfe (homologous to human H63D...

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Bibliografiske detaljer
Udgivet i:Muscle Nerve
Main Authors: SU, XIAOWEI W., NANDAR, WINT, NEELY, ELIZABETH B., SIMMONS, ZACHARY, CONNOR, JAMES R.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5848093/
https://ncbi.nlm.nih.gov/pubmed/26799243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mus.25048
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