Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer

Ovarian cancer (OC) is most lethal malignancy among all gynecological cancer. Large bodies of evidences suggest that mitochondrial-derived ROS play a critical role in the development and progression of OC. Paraoxonase 2 (PON2) is a membrane-associated lactonase with anti-oxidant properties. PON2 def...

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Publicat a:Cell Death Dis
Autors principals: Devarajan, Asokan, Su, Feng, Grijalva, Victor, Yalamanchi, Meghna, Yalamanchi, Ashna, Gao, Feng, Trost, Hannah, Nwokedi, Josephine, Farias-Eisner, Gina, Farias-Eisner, Robin, Fogelman, Alan M., Reddy, Srinivasa T
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5847560/
https://ncbi.nlm.nih.gov/pubmed/29531225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0395-2
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