Macrophage Paraoxonase 2 regulates calcium homeostasis and cell survival under Endoplasmic Reticulum stress conditions and is sufficient to prevent the development of aggravated atherosclerosis in Paraoxonase 2 deficiency/apoE(−/−) mice on a Western diet

Paraoxonase 2 deficiency (PON2-def) alters mitochondrial function and exacerbates the development of atherosclerosis in mice. PON2 overexpression protects against ER stress in cell culture. In this paper, we examined the role of PON2 in the unexplored link between ER stress and mitochondrial dysfunc...

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Main Authors: Devarajan, Asokan, Grijalva, Victor R, Bourquard, Noam, Meriwether, David, Imaizumi, Satoshi, Shin, Bo-Chul, Devaskar, Sherin U., Reddy, Srinivasa T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483415/
https://ncbi.nlm.nih.gov/pubmed/22864055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymgme.2012.06.020
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