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Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response

Hepatic glucose metabolism is strongly influenced by oxidative stress and pro-inflammatory stimuli. PON2 (paraoxonase 2), an enzyme with undefined antioxidant properties, protects against atherosclerosis. PON2-deficient (PON2-def) mice have elevated hepatic oxidative stress coupled with an exacerbat...

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Detalhes bibliográficos
Main Authors: Bourquard, Noam, Ng, Carey J., Reddy, Srinivasa T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743554/
https://ncbi.nlm.nih.gov/pubmed/21361875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20101891
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