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Pak1 Kinase Maintains Apical Membrane Identity in Epithelia

Epithelial cells are polarized along their apical-basal axis by the action of the small GTPase Cdc42, which is known to activate the aPKC kinase at the apical domain. However, loss of aPKC kinase activity was reported to have only mild effects on epithelial cell polarity. Here, we show that Cdc42 al...

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Detalles Bibliográficos
Publicado en:Cell Rep
Autores principales: Aguilar-Aragon, Mario, Elbediwy, Ahmed, Foglizzo, Valentina, Fletcher, Georgina C., Li, Vivian S.W., Thompson, Barry J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cell Press 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5847184/
https://ncbi.nlm.nih.gov/pubmed/29444419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.060
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