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Human alternative Klotho mRNA is a nonsense-mediated mRNA decay target inefficiently spliced in renal disease
Klotho is a renal protein involved in phosphate homeostasis, which is downregulated in renal disease. It has long been considered an antiaging factor. Two Klotho gene transcripts are thought to encode membrane-bound and secreted Klotho. Indeed, soluble Klotho is detectable in bodily fluids, but the...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5846909/ https://ncbi.nlm.nih.gov/pubmed/29046474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94375 |
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