SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors

Marrow-derived macrophages are highly phagocytic, but whether they can also traffic into solid tumors and engulf cancer cells is questionable, given the well-known limitations of tumor-associated macrophages (TAMs). Here, SIRPα on macrophages from mouse and human marrow was inhibited to block recogn...

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Detalhes bibliográficos
Publicado no:Curr Biol
Main Authors: Alvey, Cory M., Spinler, Kyle R., Irianto, Jerome, Pfeifer, Charlotte R., Hayes, Brandon, Xia, Yuntao, Cho, Sangkyun, Dingal, P.C.P. Dave, Hsu, Jake, Smith, Lucas, Tewari, Manu, Discher, Dennis E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846676/
https://ncbi.nlm.nih.gov/pubmed/28669759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2017.06.005
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