Dual GSK-3β/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer’s Disease Drug Discovery

[Image: see text] Designing multitarget-directed ligands (MTDLs) is considered to be a promising approach to address complex and multifactorial maladies such as Alzheimer’s disease (AD). The concurrent inhibition of the two crucial AD targets, glycogen synthase kinase-3β (GSK-3β) and human acetylcho...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Jiang, Xue-Yang, Chen, Ting-Kai, Zhou, Jun-Ting, He, Si-Yu, Yang, Hong-Yu, Chen, Yao, Qu, Wei, Feng, Feng, Sun, Hao-Peng
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846044/
https://ncbi.nlm.nih.gov/pubmed/29541355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00463
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