Discovery of the first dual GSK3β inhibitor/Nrf2 inducer. A new multitarget therapeutic strategy for Alzheimer’s disease

The formation of neurofibrillary tangles (NFTs), oxidative stress and neuroinflammation have emerged as key targets for the treatment of Alzheimer’s disease (AD), the most prevalent neurodegenerative disorder. These pathological hallmarks are closely related to the over-activity of the enzyme GSK3β...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Gameiro, Isabel, Michalska, Patrycja, Tenti, Giammarco, Cores, Ángel, Buendia, Izaskun, Rojo, Ana I., Georgakopoulos, Nikolaos D., Hernández-Guijo, Jesús M., Teresa Ramos, María, Wells, Geoffrey, López, Manuela G., Cuadrado, Antonio, Menéndez, J. Carlos, León, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5374710/
https://ncbi.nlm.nih.gov/pubmed/28361919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45701
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