Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors

[Image: see text] Ubiquitin specific protease 7 (USP7, HAUSP) has become an attractive target in drug discovery due to the role it plays in modulating Mdm2 levels and consequently p53. Increasing interest in USP7 is emerging due to its potential involvement in oncogenic pathways as well as possible...

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Pubblicato in:ACS Med Chem Lett
Autori principali: O’Dowd, Colin R., Helm, Matthew D., Rountree, J. S. Shane, Flasz, Jakub T., Arkoudis, Elias, Miel, Hugues, Hewitt, Peter R., Jordan, Linda, Barker, Oliver, Hughes, Caroline, Rozycka, Ewelina, Cassidy, Eamon, McClelland, Keeva, Odrzywol, Ewa, Page, Natalie, Feutren-Burton, Stephanie, Dvorkin, Scarlett, Gavory, Gerald, Harrison, Timothy
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5846043/
https://ncbi.nlm.nih.gov/pubmed/29541367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00512
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