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Stereochemical Structure Activity Relationship Studies (S-SAR) of Tetrahydrolipstatin
[Image: see text] Tetrahydrolipstatin (THL), its enantiomer, and an additional six diastereomers were evaluated as inhibitors of the hydrolysis of p-nitrophenyl butyrate by porcine pancreatic lipase. IC(50)s were found for all eight stereoisomers ranging from a low of 4.0 nM for THL to a high of 930...
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| Publicat a: | ACS Med Chem Lett |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical
Society
2018
|
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5846039/ https://ncbi.nlm.nih.gov/pubmed/29541373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00050 |
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