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Cryptocaryol Structure–Activity Relationship Study of Cancer Cell Cytotoxicity and Ability to Stabilize PDCD4

[Image: see text] The synthetic cryptocaryols A and B and a series of their analogues have been evaluated for their cytotoxicity and their ability to stabilize the tumor suppressor PDCD4. Cytotoxicities in the 3 to 30 μM range were found. Both the cytotoxicity and PDCD4 stabilizing ability were tole...

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Detalhes bibliográficos
Main Authors: Cuccarese, Michael F., Wang, Yanping, Beuning, Penny J., O’Doherty, George A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4029205/
https://ncbi.nlm.nih.gov/pubmed/24900873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4005039
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